Blog

About Me

Maybe life is the most complex system in our universe. I have always had a deep curiosity to understand how it works. At my second grade in Dalian Medical University, this deep curiosity drives me to catch up a chance that becoming a one year’s research fellow as an international exchange student at Okayama University in October 2014, which provides me an excellent opportunity to focus on basic scientific research. It is an excellent experience for me to finish my first real scientific project that is printed in Bone in October 2016. After the one year’s research follow, I fall in love with the basic scientific research. I am really enjoining the scientific way to find the problem, to found a hypothesis, to assemble the support evidence, and finally to finish a whole scientific project. This work in my feeling is similar to assemble a garage kit that is my favorite type of toy since my childhood.

That is the reason why I came back Okayama University to continue my research after I got the master’s degree from Dalian Medical University. At the year 2017, I think that data and computer science is more and more important for any discipline, that's why I has been further learning some programming languages (e.g., C++, R and HTML/CSS), data science and created my personal website. After all these years engaging into the scientific research, for the first time, maybe I know unknown for what it is: the shadow of our knowledge or theory system itself. Researchers are explorers to expand the border of human knowledge. The fear of uncertainty, the desperation, and all other negative emotions are always around wit researchers preparing to ruin our life. Keep deep curiosity is the only way to continue our exploration. The current theory and knowledge sometimes could blind our eyes; only the curiosity could drive us to establish something new from breaking old things.

It has been fascinating to believe that life’s diverse patterns could emerge from simple physical and chemical principle, which strongly driven me to continue my exploration. I like to read scientific articles not only in my current filed (bone and dentistry) but also from another discipline (such as economics and psychology). The interdisciplinary knowledge and the way of thinking can significantly help me to find a new point or open a new sight in my major field. It also helps me to keep strong curiosity, passion, and patience in research work.

Work Experience

Visiting Faculty | 2019 May - 2019 Oct.

Indiana University School of Medicine

Six months visiting faculty in Indiana Center for Musculoskeletal Health to learn and perform bioinformatics analysis of RNA-seq, proteomics, and metabolomics data of osteocytes generated by Dr. Bonewald’s laboratory.

During this period, learned and mastered the following skills:

1.Advance principles on the integration of genomics, proteomics, and metabolomics to discover molecular mechanisms responsible for the biology and function of osteocytes.

2.Advance principles of bioinformatics.

3.Utilize several software tools (e.g., SAMtools, Bowtie2, STAR, and TopHat) for performing bioinformatics analysis.

4.Utilize the model system based on the IDG-SW3 cell line to study osteoblast to osteocyte differentiation.

Research follow | 2014 Oct. - 2015 Sep.

Okayama University Dental School

One-year international exchange student to learn biology laboratory techniques. As research follow, learned and mastered the following skills:

1.Basic laboratory techniques.

2.Histological sample preparation.

3.Immunofluorescence technique.

4.Confocal laser scanning microscopy using and fluorescence recovery after photobleaching technique.

Dental resident | 2014 Feb. - 2014 Sep.
| 2015 Oct. - 2016 Sep.

General Hospital of Shenyang Military Command

Learned and mastered the following skills during these periods:

1.Orthodontic diagnosis (patient interview, orthodontic oral examination, and cephalometrics) and treatment planning (development&prioritization of the problem list, development of treatment objectives, evaluation of possible solutions, visualized treatment objective).

2.Fixed&removable orthodontic appliances, clear aligners (Invisalign), management of temporomandibular joint dysfunction during orthodontic treatment.

Dental Student | 2012 Jul. ~ 2013 Aug.

Shenzhen Hospital of Guangzhou University of Chinese Medicine

Learned and mastered the following skills during the internship:

1.Endodontics: basic endodontic treatment procedures (access preparation by endodontic motors with Ni-ti files and downpack-backfill obturation techniques), basic treatment for traumatic injuries.

2.Operative Dentistry: treatment planning for dental caries, preparation and restoration of teeth, chairside CAD/CAM inlays and onlays.

3.Periodontics: scaling and root planing.

4.Dentoalveolar Surgery: local anesthesia, dental extractions (primary/permanent teeth and third molar extraction), reduction of a temporomandibular joint dislocation.

5.Prosthodontics: removable partial prosthodontics, fixed prosthodontics, esthetic restorations of anterior teeth (porcelain veneers and smile designing).

6.Oral prophylaxis: laser teeth whitening，fissure sealants.

Education

PhD (Orthodontics) | 2016 Oct. ~ present

Okayama University

Okayama University originates from the Medical Training Place Sponsored by the Lord of Okayama founded in 1870 by the family of Lord Ikeda who already founded the domain school for the samurai that continued for 200 years. This medical school was reorganized several times and became Okayama Medical College in 1922, and several schools such as Okayama Medical School and the Sixth Higher School were established as Okayama National University in 1949. In 2004, Okayama National University was reorganized as a National University Corporation.

Master (Orthodontics) | 2013 Sep. ~ 2016 Jun.

Dalian Medical University

Founded in 1947, with former name of Kanto Medical School, Dalian Medical Univeristy was incorporated in to Dalian University in 1949 and named Medical School of Dalian University. It was separated from Dalian University in 1950 and named Medical School of Dalian University. In 1969, it was immigrated to Zunyi, Guizhou Province and called Unyi medical School. While Dalian Medical School was reestablished in the original address in 1978 and renamed as Dalian Medical University in 1994. Now it has been a medical university with main feature of medicine education and comprehensive development of several subjects including science, engineering, management, art, law and philosophy, etc.

Bachelor (Stomatology) | 2008 Sep. ~ 2013 Jun.

Foshan University

Foshan University is a designated full-time comprehensive university located in Foshan, Guangdong province, China. The university is a merger between its predecessor and Foshan Agriculture&Animal Husbandry College approved by the Chinese Education Ministry and comes under the administration of the Guangdong provincial government and Foshan local government in 1995.

Skills

Dentist 85%
Biologist 50%
Data Analyst50%
Programmer 30%
Photographer 15%
Mathematics 1%

My Projects

Publications

First Author

1. Ziyi Wang, Yao Weng, et al. "Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes." PeerJ. 2020.
| In Revision |

2. Ziyi Wang, Yoshihito Ishihara, et al. "Screening of key candidate genes and pathways for osteocytes involved in the differential response to different types of mechanical stimulation using a bioinformatics analysis." Journal of Bone and Mineral Metabolism. 2019;37(4):614-626.
| Impact Factor & Rank in Publication Year : 2.310 & Q3 |

3. Ziyi Wang, and Hiroshi Kamioka. "The temporospatial pattern of energy metabolism coordinates the interactions between the bones and other organ systems." Journal of Oral Biosciences. 2017;60(1):8-14.
| Included by SCIE with CiteScore of 1.4 |

4. Ziyi Wang, et al. "Alternation in the gap-junctional intercellular communication capacity during the maturation of osteocytes in the embryonic chick calvaria." Bone. 2016;91:20-29.
| Impact Factor & Rank in Publication Year : 4.140 & Q1 |

Co-First Author

5. Ryuta Osumi, Ziyi Wang, et al. "Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading." Journal of Bone and Mineral Metabolism. 2020.
| In Press |

Co-authorship

6. Jiajie Guo, Ziyi Wang, et al. "N-(3-oxododecanoyl)-homoserine lactone regulates osteoblast apoptosis and differentiation by mediating intracellular calcium." cellular signalling. 2020
| In Press |

7. Ei Ei Hsu Hlaing, Yoshihito Ishihara, Naoya Odagaki, Ziyi Wang, et al. "Expression and regulation of Wnt1 in tooth movement-initiated mechanotransduction.” American Journal of Orthodontics and Dentofacial Orthopedics." American Journal of Orthodontics and Dentofacial Orthopedics. 2020
| In Press |

8. Yuhan He, Noriko Shiotsu, Yoko Uchida-Fukuhara, Jiajie Guo, Yao Weng, Mika Ikegame, Ziyi Wang, et al. "Outer membrane vesicles derived from Porphyromonas gingivalis induced cell death with disruption of tight junctions in human lung epithelial cells." Archives of Oral Biology. 2020;18:104841-10424.
| Impact Factor & Rank in Publication Year : Not yet available |

9. Ei Ei Hsu Hlaing, Yoshihito Ishihara, Ziyi Wang, et al. "Role of intracellular Ca2+–based mechanotransduction of human periodontal ligament fibroblasts." The FASEB Journal. 2019;33(9):10409-10424.
| Impact Factor & Rank in Publication Year : 4.966 & Q1 |

10. Jun Li, Ziyi Wang, Xiaodong Zhang. "CBCT Analysis of Mesiodistal Angulation of Maxillary Molars for Female Patient with Skeletal Class II Malocclusion." Journal of Oral Science Research. 2018;34(8):896-901.
| Peer Reviewed Chinese Article |

11. Naoya Odagaki, Yoshihito Ishihara, Ziyi Wang, et al. "Role of Osteocyte-PDL Crosstalk in Tooth Movement via SOST/Sclerostin" Journal of Dental Research. 2018;97(12):1374-82.
| Impact Factor & Rank in Publication Year : 5.380 & Q1 |

12. Yao Weng, Ziyi Wang, Xiaodong Zhang. "Optimization for landmarks-based three-dimensional cephalometric superimposition and a method for superimposition of three-dimensional image of maxilla." Chinese Journal of Medical Imaging Technology. 2017;33(1):124-31.
| Peer Reviewed Chinese Article |

Chapter in Book

13. Ziyi Wang, Yoshihito Ishihara, and Hiroshi Kamioka. "The analysis of gap junctional intercellular communication among osteocytes in chick calvariae by fluorescence recovery after photobleaching." Kursad Turksen, ed., Cell-to-Cell Communication 2nd, Springer US, Boston, MA, 2021. (Springer Protocols)

In Acknowledgements

14. Shanqi Fu, Miho Kuwahara, Yoko Uchida, Sei Koudo, Daichi Hayashi, et al. "Circadian production of melatonin in cartilage modifies rhythmic gene expression." Journal of Endocrinology. 2019. (In Press)
| Impact Factor & Rank in Publication Year : 4.041 & Q2 |

Published Software in Academic Article

9. Ei Ei Hsu Hlaing, Yoshihito Ishihara, Ziyi Wang, et al. "Role of intracellular Ca2+–based mechanotransduction of human periodontal ligament fibroblasts." The FASEB Journal. 2019;33(9):10409-10424.
| Impact Factor & Rank in Publication Year : 4.966 & Q1 |

14. Shanqi Fu, Miho Kuwahara, Yoko Uchida, Sei Koudo, Daichi Hayashi, et al. "Circadian production of melatonin in cartilage modifies rhythmic gene expression." Journal of Endocrinology. 2019. (In Press)
| Impact Factor & Rank in Publication Year : 4.041 & Q2 |

Conference

1. Ziyi Wang. "Investigate the mechanotransduction of osteocytes: start with bioinformatics." Advanced Dental School 2018 Program. Tokyo, Japan. (Aug. 2018)
| Oral Presentation Number : 5 | Website | Slides

2. Ziyi Wang, Yoshihito Ishihara, Takanori Ishikawa, Mitsuhiro Hoshijima, Naoya Odagaki, Ei Ei Hsu Hlaing, Hiroshi Kamioka. "Screening of key candidate genes and pathways for osteocytes involved in the differential response to different types of mechanical stimulation using a bioinformatics analysis." The 15th Bone Biology Forum. Tokyo, Japan. (Aug. 2018)
| Oral Presentation Number : 6 | Website | Slides

3. Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Ei Ei Hsu Hlaing, Hiroshi Kamioka. "Mechanical signals influence circadian clock genes in murine osteocytes: implications for spatial distribution of sclerostin" The 36th Annual Meeting of the Japanese Society for Bone and Mineral Research. Nagasaki-shi, Nagasaki, Japan. (Jul. 2018)
| Poster Presentation Number : P1-15 | Website | Poster

4. Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Ei Ei Hsu Hlaing, Hiroshi Kamioka. "Expression change of circadian clock genes in murine osteocytes by mechanical stimuli: implications for spatial distribution of sclerostin." The 38th Annual Meeting of Japanese Society for Bone Morphometry. Osaka, Japan. (Jun. 2018)
| Oral Presentation Number : II - 6 | Website | Slides

5. Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Masahiro Nakamura, Ei Ei Hsu Hlaing, Hiroshi Kamioka. "Evidence for the bone structure change and osteocytes’ biorhythm during orthodontic tooth movement." The 76th Annual Meeting of the Japanese Orthodontic Society. Sapporo, Hokkaido, Japan. (Oct. 2017)
| Poster Presentation Number : AE-006 | Website | Poster

6. Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Hiroshi Kamioka. "Detection of the bone structure change and periodic osteocytes' expression of sclerostin during orthodontic tooth movement." The 59th Annual Meeting of Japanese Association for Oral Biology. Shiojiri, Nagano, Japan. (Sep. 2017)
| Oral Presentation Number : 01-D17 | Website | Slides

7. Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Masahiro Nakamura, Ei Ei Hsu Hlaing, Hiroshi Kamioka. "Fast Fourier Transform Analysis Showed Morphological Change of Bone Structure and Change of Periodicity of Sclerostin Expression during Orthodontic Tooth Movement." American Society for Bone and Mineral Research 2017 Annual Meeting. Denver, Colorado, USA. (Sep. 2017)
| Poster Presentation Number : SA0116 | Website | Poster

8. Ziyi Wang, Naoya Odagaki, Tomoyo Tanaka, Mana Hashimoto, Hiroshi Kamioka. "Alternation in Gap-junctional Intercellular Communication Capacity During the Ex Vivo Transformation of Osteocytes in the Embryonic Chick Calvaria." American Society for Bone and Mineral Research 2016 Annual Meeting. Atlanta, Georgia, USA. (Sep. 2016)
| Poster Presentation Number : SU0179 | Website | Poster

9. Ziyi Wang, Naoya Odagaki, Tomoyo Tanaka, Mana Hashimoto, Hiroshi Kamioka. "Alternation in Gap-junctional Intercellular Communication Capacity During the Ex Vivo Transformation of Osteocytes in the Embryonic Chick Calvaria." The 34th Annual Meeting of the Japanese Society for Bone and Mineral Research. Osaka, Japan. (Jul. 2016)
| Poster Presentation Number : P 2 - 53 | Website | Poster

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